Endocrine Abstracts

Objective: Inferior petrosal sinus sampling (IPSS) with CRH stimulation is considered the gold standard for the differential diagnosis of ACTH-dependent Cushing’s syndrome. The aim of this study is to evaluate its role in confirmation and lateralisation of a pituitary source in suspected Cushing’s disease (CD).Methodology: Nine patients with CD with indeterminate MRI underwent IPSS from August 2004 to February 2007. Three were being assessed fo...

Background: The diagnosis of central diabetes insipidus (DI) relies on indirect measurement of serum/urine sodium and osmolality. Since the diagnosis can only be made when an inappropriately dilute urine is paired with a significantly concentrated serum, the process is tedious for the clinician and uncomfortable for the patient. Copeptin is the C-terminal portion of the anti-diuretic hormone (ADH) prohormone which correlates with the less stable ADH, therefore providing a dire...